sustaInaBle Improvement In sheep productIvIty In IndIa usIng the FecB (Booroola) mutatIon
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DETECTION OF POLYMORPHISM IN BOOROOLA GENE (FecB) AND ITS ASSOCIATION WITH LITTER SIZE IN ZEL SHEEP BREED IN IRAN
Sixty eight adult ewes of Zel sheep breed were screened with forced PCR RFLP method for the detection of the FecB gene and its effects on litter size. Genomic DNA was extracted from the blood of 68 Zel matured ewes with litter size varied from 1 to 2 lambs per ewe lambing. Digestion of the FecB gene (190 base pairs) with AvaII restriction enzyme resulted in none carrier 190 bp band wild type in...
متن کاملThe Booroola mutation in sheep is associated with an alteration of the bone morphogenetic protein receptor-IB functionality.
The hyperprolificacy phenotype of Booroola ewes is due to the presence of the FecB(B) allele at the FecB locus, recently identified as a single amino acid substitution (Q249R) in the bone morphogenetic protein (BMP) type-IB receptor (BMPR1B), and is associated with a more precocious differentiation of ovarian granulosa cells (GCs). To evaluate the consequences of the Booroola mutation on BMPR1B...
متن کاملMutations in BMPR-IB and BMP-15 genes are associated with litter size in Small Tailed Han sheep (Ovis aries).
The Small Tailed Han is a prolific local sheep breed in China. The bone morphogenetic protein receptor IB (BMPR-IB) gene, which affects the fecundity of Booroola Merino sheep, and the bone morphogenetic protein 15 (BMP-15) gene, which affects the fecundity of Inverdale, Hanna, Belclare, Cambridge, and Lacaune sheep, were studied as candidate genes associated with the prolificacy of Small Tailed...
متن کاملMutation in bone morphogenetic protein receptor-IB is associated with increased ovulation rate in Booroola Mérino ewes.
Ewes from the Booroola strain of Australian Mérino sheep are characterized by high ovulation rate and litter size. This phenotype is due to the action of the FecB(B) allele of a major gene named FecB, as determined by statistical analysis of phenotypic data. By genetic analysis of 31 informative half-sib families from heterozygous sires, we showed that the FecB locus is situated in the region o...
متن کاملAllelic and genotypic frequencies in polymorphic Booroola fecundity gene and their association with multiple birth and postnatal growth in Chhotanagpuri sheep
AIM Chhotanagpuri breed of sheep reared for mutton in Jharkhand, India, having problem of low litter size and body weight. The response of genetic improvement for traits with low heritability through traditional selection method is time-consuming. Therefore, marker-assisted selection based on a polymorphism study of suitable candidate gene can response quickly. Thus, this study was aimed at ide...
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